The Colon Lady
Back in the day, commercials about the grosser bodily functions would genteelly talk around the topic (see Charmin above). Today, the preferred approach is to never shut up about it. Enter Marge Royce, AKA Colon Lady, the amazingly annoying pitchwoman for Phillips' Colon Health who talks about the nastiest things with total strangers at airports, bookstores and yes, even weddings. Which raises the obvious question: What does she have left to talk about when she goes to the powder room?
What TV commercial spokespeople make you instantly reach for the remote?